Nicotine Material Safety Data Sheet(s)
Other Material Safety Information for Nicotine:
l-Nicotine, 99+%
96314
**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: l-Nicotine, 99+%
Catalog Numbers:
AC181420000, AC181420050, AC181420250, AC181421000
Synonyms:
S-(-)-Nicotine, B-Pyridyl-a-N-Methylpyrrolidine.
Company Identification: Acros Organics N.V.
One Reagent Lane
Fairlawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 54-11-5 |Nicotine | 99 | 200-193-3 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: T+
Risk Phrases: 25 27
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: colorless to light yellow.
Danger! May be fatal if swallowed. May be fatal if absorbed through
the skin. Hygroscopic. This substance has caused adverse
reproductive and fetal effects in animals. May cause central nervous
system depression. Poison! May cause cardiac disturbances. May cause
digestive tract irritation with nausea, vomiting, and diarrhea.
Target Organs: Central nervous system, respiratory system, muscles.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be fatal if absorbed through the
skin.
Ingestion:
May be fatal if swallowed. May cause adverse effects of the
musculature. May cause severe digestive tract irritation with
abdominal pain, nausea, vomiting and diarrhea. May cause tremors and
convulsions. May cause muscle paralysis, respiratory failure, and
possible death.
Exposure causes initial nervous system stimulation followed by severe
CNS depression. May cause ataxia and incoordination.
Inhalation:
May cause effects similar to those described for ingestion.
Chronic:
May cause digestive tract and cardiac disturbances.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes
while removing contaminated clothing and shoes. Get medical aid if
irritation develops or persists. Discard contaminated clothing in a
manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air
immediately. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Can form explosive mixtures at temperatures above
the flashpoint. Vapors may be heavier than air. They can spread
along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use water spray, dry chemical, carbon dioxide or
chemical foam. Water or foam may cause frothing.
Autoignition Temperature: 240 deg C ( 464.00 deg F)
Flash Point: 101 deg C ( 213.80 deg F)
NFPA Rating: health-4; flammability-1; reactivity-0
Explosion Limits, Lower: .70 vol %
Upper: 4.00 vol %
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Wear a self contained breathing apparatus and appropriate Personal
protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Absorb spill using an absorbent,
non-combustible material such as earth, sand, or vermiculite.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Use with adequate ventilation. Ground and bond
containers when transferring material. Use spark-proof tools and
explosion proof equipment. Do not reuse this container. Do not get
on skin or in eyes. Do not ingest or inhale.
Storage:
Keep away from sources of ignition. Keep from contact with oxidizing
materials. Store in a cool, dry, well-ventilated area away from
incompatible substances. Keep away from strong acids.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne
concentrations below the permissible exposure limits.
Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
| Chemical Name | ACGIH | NIOSH |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| Nicotine |0.5 mg/m3; skin - |0.5 mg/m3 TWA 5 |0.5 mg/m3 TWA |
| |potential for | mg/m3 IDLH | |
| |cutaneous | | |
| |absorption | | |
+--------------------+-------------------+-------------------+-----------------+
OSHA Vacated PELs:
Nicotine:
0.5 mg/m3 TWA
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear impervious gloves.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator
when necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State: Liquid
Appearance: colorless to light yellow
Odor: Slight fish odor when warm.
pH: 10.2
Vapor Pressure: 1 mm Hg @ 61.8C
Vapor Density: 5.61 (air=1)
Evaporation Rate: Not available.
Viscosity: exposure to air
Boiling Point: 247 deg C @ 760.00mm Hg
Freezing/Melting Point: -80 deg C
Decomposition Temperature: Not available.
Solubility: IN WATER: MISCIBLE BELOW 60ŚC
Specific Gravity/Density: 1.0100g/cm3
Molecular Formula: C10H14N2
Molecular Weight: 162.23
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room temperature in closed containers under normal storage
and handling conditions.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong acids, strong oxidizers.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 54-11-5: QS5250000
LD50/LC50:
CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50
mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg.
Carcinogenicity:
Nicotine -
Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
No information available.
Teratogenicity:
Effects on Newborn: Biochemical and metabolic, orl-rat
TDLo=59400 ug/kg; Stillbirth, scu-rat TDLo=9 mg/kg. Embryo or Fetus:
Death, ipr-mouse TDLo=24 mg/kg; Stunted fetus, ipr-rat TDLo=5250 ug/kg.
Specific Developmental Abnormalities: Craniofacial, ipr-mouse
TDLo=1 mg/kg; Musculoskeletal, orl-mouse TDLo=16 mg/kg.
Reproductive Effects:
Fertility: Litter size, scu-mouse TDLo=25 mg/kg. Maternal Effects:
Postpartum effects, scu-rat TDLo=22500 ug/kg.
Neurotoxicity:
No information available.
Mutagenicity:
DNA Inhibition: rbt-cell types 1mmol/L.
Other Studies:
Please refer to RTECS QS5250000 for additional data.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Fish (fresh water) 3-29ppm toxic (time period not specified).
Environmental Fate:
No information reported.
Physical/Chemical:
No information available.
Other:
None.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
RCRA D-Series Maximum Concentration of Contaminants:
None listed.
RCRA D-Series Chronic Toxicity Reference Levels: None
listed.
RCRA F-Series: None listed.
RCRA P-Series: CAS# 54-11-5: waste number P075.
RCRA U-Series: None listed.
CAS# 54-11-5 is banned from land disposal according
to RCRA.
**** SECTION 14 - TRANSPORT INFORMATION ****
US DOT
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: 1654
Packing Group: II
IMO
No information available.
IATA
No information available.
RID/ADR
No information available.
Canadian TDG
Shipping Name: NICOTINE
Hazard Class: 6.1
UN Number: UN1654
**** SECTION 15 - REGULATORY INFORMATION ****
US FEDERAL
TSCA
CAS# 54-11-5 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
CAS# 54-11-5: final RQ = 100 pounds (45.4 kg)
Section 302 (TPQ)
CAS# 54-11-5: TPQ = 100 pounds; RQ = 100 pounds (calculated TPQ change
d after technical review as described in the technical support docume
nt)
SARA Codes
CAS # 54-11-5: acute, chronic.
Section 313
This material contains Nicotine (CAS# 54-11-5, 99%),which is subject
to the reporting requirements of Section 313 of SARA Title III and
40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
None of the chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
Nicotine can be found on the following state right to know lists:
California, New Jersey, Florida, Pennsylvania, Minnesota,
Massachusetts.
WARNING: This product contains Nicotine, a chemical known to the
state of California to cause birth defects or other reproductive
harm.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 25 Toxic if swallowed.
R 27 Very toxic in contact with skin.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident of if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 54-11-5: No information available.
Canada
CAS# 54-11-5 is listed on Canada's DSL/NDSL List.
This product has a WHMIS classification of D1A, D2B.
CAS# 54-11-5 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 54-11-5: OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin
OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin
OEL-BELGIUM:TWA 0.5 mg/m3;Skin
OEL-DENMARK:TWA 0.5 mg/m3;Skin
OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin
OEL-FRANCE:TWA 0.5 mg/m3;Skin
OEL-GERMANY:TWA 0.07 ppm (0.5 mg/m3);Skin
OEL-HUNGARY:STEL 0.5 mg/m3;Skin
OEL-THE NETHERLANDS:TWA 0.07 ppm (0.5 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin
OEL-POLAND:TWA 0.5 mg/m3
OEL-SWITZERLAND:TWA 0.07 ppm (0.5 mg/m3);STEL 0.1 ppm;Skin
OEL-THAILAND:TWA 0.5 mg/m3
OEL-TURKEY:TWA 0.5 mg/m3;Skin
OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 2/01/1996 Revision #1 Date: 12/16/1997
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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