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J.Phar.Sci.v. 54(2) Feb-1965 p.319-321
"Reaction of Piperine with nitric acid" Graham
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Photooxygenation reactions of natural piperine.
Ayyad, S.N., Elgendy, E.M., Mansoura Sci. Bull., A: Chem. 24(1, Suppl. 2): 207-11 (1997).
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CHEMISTRY OF PIPERINE
=====================

http://www.bioperine.com/Manual/ChemistryOfPiperine1.htm
mit piperine-bild mit transparentem hintergrund

http://www.bioperine.com/Manual/References1.htm
quellen
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roempp-cd-rom: piperin
======================

Remsen

Ira (18461927), Prof. für Organ. Chemie, Johns Hopkins Univ., Baltimore (USA). 
Arbeitsgebiete: Entdeckung des Saccharins (zusammen mit Fahlberg), Konstitution von Piperin, 
Begründer des American Chemical Journal.

Lit.: Chem. Unserer Zeit 20, A 37, 47 (1986) ï Neufeldt, S. 71 ï Pötsch, S. 360.



Quelle: Römpp Lexikon Chemie  Version 2.0, Stuttgart/New York: Georg Thieme Verlag 1999
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refs: piperin isolation
=======================

http://www.thioxazobiotechlab.com/NEWSLETPIP.html

  
  
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                                                                                                                              NEWS LETTER
NEW AMIDES  FROM PIPERINE -  A NATURAL ALKALOID WITH POTENTIAL INSECTICIDAL AND OTHER PHARMACOLOGICAL ACTIVITY. 
  

           The insecticidal properties of black pepper extracts were discovered as early as 1924.  Piperine is the major constituent found in Piper nigrum and it was
found to be toxic to domestic fly.  The potential of this class of compounds as a model for the development of pesticides has been investigated by several
researchers. 

         Several new amides were described from piperic acid (obtained by hydrolysis of piperine).   [ Synthesis and insecticidal activity of new amide derivatives of
piperine.   Vanderlu?cia F de paula et al, Pest Manag. Sci., 56, 768-174,2000]. 

         synthesis of a number of amide with piperic acid using heterocyclic amines.  Such as amino derivatives of   flavones, coumarins and several other nitrogen
heterocyclics will be rewarding.These heterocyclics are known to  elaborate insecticidal activity. These compounds may exhibit wide range of other pharmacological
activities also. 
    Piperine was also isolated from Piper longum . 
Papers of related interest : 

1.    SUHCF et al, Isolation, identification and insecticidal properties of Piper nigrum amides, J. Agric Food Chem., 29, 115-118 (1981). 

2.    Miyakado M. et al,   The Piperaceae amides 6.  Chemisty and insecticidal activity of Piperaceae amides and their synthetic analogues. J. Pest. Sci.,10, 11-17,
1985. 
3.     Miyakado M. et al,  Insecticidal unsaturated isobutyl amides, in ?Insecticides of Plant Origin? ed. By Arnason J.T. et al, ACS symposium series 387, Maple
Press, New York, pp173-187,1989. 
                                                                                                                              NEWS LETTER 
                                                                                                                                    HOME

  
Knowledge of indigenous  people (tribals) is essentials for  chemists.Digitoxin (from  Digitalis species, quinine (from Cinchona species),Cocaine  (from
Erythroxylum species),Atropa (Atropa belladona) ,Asprin (Salix species), and Reserpin (Rauwolfia serpentina) were only  few examples where indigenous
people contributed to modern medicine.


                                      For further information contact:  director@thioxazobiotechlab.com 
                                                               ©copy rights reserved
------------------------------------------------------------------------------------------
http://www.aluinfo.de/download/Arbeitsblaetter(1).pdf

1819 hans christian oersted
isolierung von pierin aus pfeffer
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http://food.orst.edu/ref/g-1970.html

JOURNAL OF FOOD SCIENCE, 1965, 30, 651
"QUANTITATIVE DETERMINATION OF PIPERINE. II. DIRECT DETERMINATION WITH PHOSPHORIC ACID"
GRAHAM, H. D.

JOURNAL OF FOOD SCIENCE, 1965, 30, 644
"QUANTITATIVE DETERMINATION OF PIPERINE. I. THE KOMAROWSKY REACTION"
GRAHAM, H. D.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1963, 11, 508
"PEPPER ANALYSIS, A CRITICAL STUDY OF TWO PROCEDURES FOR THE DETERMINATION OF PIPERINE IN BLACK AND WHITE PEPPER"
GENEST, C.; SMITH, D. M.; CHAPMAN, D. G.
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J Chromatogr  1983 Jul 15;264(2):316-20 
"Determination of piperine in pepper (Piper nigrum) using high-performance 
liquid chromatography."
Rathnawathie M, Buckle KA.

PMID: 6885950 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6885950&dopt=Abstract
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L. Rügheimer, " Künstliches Piperin ", Ber.  15 1390 (1882)
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Supercritical fluid extraction in the quality control of piperine.

Yuan, Yong-Fang; Bian, Jun; Zhou, Jian; Shi, Lifu (Department of Pharmacy, Changhai 
Hospital, Shanghai 200433, Peop. Rep. China).  Zhongguo Yaoke Daxue Xuebao, 31(3), 199-202 
(Chinese) 2000 Zhongguo Yaoke Daxue.  CODEN: ZHYXE9.  ISSN: 1000-5048.  DOCUMENT TYPE: 
Journal CA Section: 63 (Pharmaceuticals)

A Supercrit. Fluid Extn. (SFE) method was developed for the extn. of effective components in 
Piper longum L.  The optimal extn. conditions of SFE were designed.  The comparison was 
conducted between SFE and traditional org. extn.  The optimal SFE conditions were that: (1) 
alc. was used as a modifier of supercrit. fluid CO2 and (2) the sample was extd. by this 
supercrit. fluid in statics for 15 min and then 5 mL dynamically at 40 and 2. 068 X 107 
Pa(3000Psi).  The method was simple, rapid, perfect, and its extn. rate was higher than that 
by org. solvent extn.
------------------------------------------------------------------------------------------
from CA 2002:
=============

The process comprises extg. pepper with mixed solvent at 25-40° for 1-6 h, filtering, 
concg., crystg., and recrystg. with dichloroethylene or Et acetate.  The mixed solvent is 
ethanol, methanol, acetone, Et ether, Et acetate, dichloromethane, benzene, and/or 
chloroform.

---------------------------------------------

Process for preparing piperine 

  Patent Number:
             CN1294127 
  Publication date:
             2001-05-09 
  Inventor(s):
             SHI ZAIFENG (CN); SUN ZHENFAN (CN); LIN XIAOMING (CN) 
  Applicant(s):
             LUTIANYUAN HI TECH DEV CO LTD (CN) 
  Requested Patent:
             CN1294127 
  Application Number:
             CN20000130395 20001103 
  Priority Number(s):
             CN20000130395 20001103 
  IPC Classification:
             C07D317/50; C07D295/182; C07D211/40; C07G5/00 
  EC Classification:
              
  Equivalents:
              


                                         Abstract

  A process for preparing piperine includes immersing extraction of pepper is mixed organic 
solvent, distilling to separate out organic solvent to obtain liquid

  mixture of pepper oil resin and piperine, cooling to separate out the pepper oil resin, 
and further purifying. Its advantages are simple process, high extraction rate

  and separation effect, and high purity.

                               Data supplied from the esp@cenet database - l2
------------------------------------------
------------------------------------------
Process for piperine resin preparation from pepper powders.

Lin, Xiaoming; Shi, Zaifeng; Sun, Zhenfan (Lutianyuan High and New Technology Development 
Co., Ltd., Hainan Province, Peop. Rep. China).  Faming Zhuanli Shenqing Gongkai Shuomingshu 
CN 1290730 A 11 Apr 2001, 5 pp.  (Chinese). (People's Republic of China).  CODEN: CNXXEV.  
CLASS: ICM: C09F001-00.  APPLICATION: CN 2000-130396 3 Nov 2000.  DOCUMENT TYPE: Patent CA 
Section: 37 (Plastics Manufacture and Processing)

The process comprises: smashing dried black (or white) pepper to powder with av. diam. <2 
mm, mixing the powder with mixed org. solvent with a ratio of solvent/pepper=1/1-6/1, 
stirring the mixt. at 25-40° for 1-6 h, sepg. by filtering to obtain leaching liquor, distg. 
to remove org. solvent and collecting the resin contg. high piperine, wherein the solvent is 
selected form ethanol, methanol, acetone, Et ether, Et acetate, ethylene dichloride, benzene 
and trichloromethane.
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